In recent years, the once-thriving momentum of globalization has stagnated, deviating from the rapid global integration seen in the early twenty-first century. What forces are reshaping the global supply chain? In this chapter, we’ll delve into how the reshaping of the global supply chain is influenced by the unraveling of the global multilateral trade system. The WTO, once an arbitrator in global trade disputes, has lost its influence in trade disputes. In such environment, businesses are compelled to confront increased risks and uncertainties. Moreover, efficiency and comparative advantages are no longer the sole benchmarks for establishing supply chains. Resilience has become an equally important objective, leading to the reshaping of the global supply chain. This is manifested in trends like reshoring, nearshoring, and friendshoring, where businesses aim to gain better control over their upstream supply chains. This shift reflects the fact that businesses are re-evaluating the geographical layout of their supply chains to reduce risks, enhance efficiency, and address the uncertainties of the broader environment.