In recent years, with the development of the digital economy, enterprises have been constantly constructing platforms and ecosystems. Research on innovation and entrepreneurial ecosystems, with its unique ecosystem perspective, provides key support for understanding and predicting innovation-driven entrepreneurship theory and practice. Through a theoretical review, this chapter focuses on ecosystem theory, explaining the origins, development and breakthrough of innovation ecosystems and entrepreneurial ecosystems respectively. Besides, driven by either the practical need for innovation and entrepreneurship or the theoretical development of innovation and entrepreneurship research, innovation and entrepreneurial ecosystems are converging toward integration. We set forth the application and prospects of innovation and entrepreneurial ecosystems research, which may enrich the ecosystem theory in the context of innovation-driven entrepreneurship.