This study explores the context of blood donation in Portugal, specifically aiming to understand how communication strategies can effectively recruit young blood donors aged 18 to 24. The research addresses the following question: What is the impact of communication efforts on the recruitment of young blood donors in Portugal? To answer this question, four specific objectives were set: (1) To evaluate the level of awareness among young individuals in this age group regarding blood donation; (2) to analyze and assess the communication strategies employed by the Portuguese Institute of Blood and Transplantation (IPST) to promote blood donation; (3) to investigate the motivations and barriers related to blood donation; and (4) to identify effective communication strategies for encouraging blood donation. To achieve the first objective, which is the primary focus of this article, a content analysis of 14 blood donation campaigns was conducted. For the second objective, an exploratory interview was held with a specialist from the IPST. The third objective is being addressed through a survey involving 390 young individuals, which has already been administered and revealed that over half of the respondents are not blood donors. The findings suggest that future campaigns should adopt more targeted segmentation strategies based on behavioral criteria and make greater use of integrated marketing communication to enhance effectiveness.