Urbanization, industrialization, mining, agriculture, and exploration are all major contributors to environmental pollution. Environmental pollutants affect living organisms’ growth, development, physiological, biochemical, metabolic, defense, and immunity pathways. Ultimately, this leads to morbidity and mortality. Nowadays, heavy metal (HM) or metalloid contamination is a major problem in agricultural soil worldwide. It not only contaminates the soil but also hurts crop productivity, quality, and safety. HM contamination in agrarian soil may lead to health risks and hazards to humans via the food chain. Remediation of HM-contaminated soils is required to eliminate the associated risks and make the agricultural land resource available for crop production. Nowadays, scientists are looking for the future of world health through bioremediation strategies. Bioremediation is an emerging technology that effectively manages various environmental pollutants, especially HM-contamination. The process of bioremediation involves the utilization of biological systems for either restoring or cleaning up contaminated sites. It is a promising approach to environmental pollution management, especially eliminating HMs. This chapter presents the details of various bioremediation approaches for HMs elimination from agricultural soil. We also highlight the available innovative approaches for HM remediation technologies. Moreover, we describe the status of HM contamination in the environment and its impact on human beings. This chapter could help researchers understand the available strategies for HM bioremediation in agricultural soil for a better life.