The immune response is a biological control mechanism to confer defences against noxious stimuli triggered by invading microbes or intrinsic signals such as damaged cells. The immune system is distributed across the entire body and is a complex assemblage of organs, tissues, cells, and soluble substances. However, self-perpetuation and over-aggravation of immune system are also responsible for a variety of diseases in humans. Ayurveda, as the science of life, promotes utilizing nature’s resources to live a healthy and happy lifestyle. It is a plant-based science, practiced traditionally and scientifically proven as immune modulators for various inflammatory, infectious, and metabolic disorders. Several Ayurveda plants, decoctions, and formulations are well known for their various health beneficial effects. The above -mentioned Nutri-Ayurvedics have been shown to play a significant role in regulating various vital cell signalling pathways involved in different anomalies. They also play an essential role in immunity by interfering with innate and adaptive immune cell regulation, especially proinflammatory cytokine synthesis and cell activation. Considering this, nowadays, most of the natural Ayurveda plants and products are processed and developed as immunomodulators and immunosuppressants with effective anti-oxidative, anti-mitotic, anti-inflammatory, antiangiogenic, and anticarcinogenic properties for their intended therapeutic use. In this chapter, we discuss different practised Ayurveda plants, herbs, and formulations as nutraceutical or nutritionals for their biological potential and how these molecules regulate innate and adaptive immune responses. We have also discussed and compared the depth of knowledge available from previous works, which emphasizes the importance of developing plant-extract-based and bioactive constituent-based preventive and therapeutic approaches as alternatives to synthetic counterparts.