Personal information privacy protection is an important issue in the digital age. Artificial intelligence technology has been rapidly developed and widely used, and the data analysis and processing capabilities of artificial intelligence have been continuously improved. Despite this, privacy security risks remain. Abuses of personal information can cause security problems, such as abuse of user identity and privacy information leakage. In this article, we describe a personal privacy information protection application based on artificial intelligence algorithms, including a method and research conclusions. The application recognizes the personal information sensitivity during the process of entering user data and desensitizes the data to protect user personal privacy information. The experiments showed that the application had good performance in personal information sensitivity recognition, privacy protection effectiveness verification, and prediction accuracy. Additionally, the application is customized and expandable to support different data types and use scenarios. The experimental results show that personal privacy information protection based on an artificial intelligence algorithm can provide an effective scheme and guarantee for the protection of a user's personal privacy information.