In the process of deep and ultra deep processing in Central S Basin, due to the development of deep multiples, most of the internal seismic synthetic records of interval Z layer are seriously mismatched with the actual seismic records, resulting in unclear seismic response of high-yield wells and difficulty in seismic reservoir prediction, which directly affects the effective development of gas reservoirs. There are many multiple sources in the deep layer of S Basin, and the multiple fields are mixed with each other, so the model prediction has strong multiple solutions; The variable surface conditions and the strong heterogeneity of underground media lead to the unstable development of multiples, and it is difficult to separate effective multiples, which is easy to cause deep weak effective signal damage. In this paper, the well drive extended SRME interlayer multiple suppression technology based on numerical simulation identification is adopted, which breaks through the dilemma that the existing methods are difficult to work because of the small velocity difference between the interlayer multiple and the primary wave, and realizes the effective separation of multiple under the protection of deep weak effective signal, the matching degree of well and earthquake has been greatly improved, and an effective and reproducible suppression scheme suitable for onshore deep multiples has been formed.