To study the influence of process parameters on the effect of tobacco packet rewetting, a model of tobacco packet rewetting was constructed. A single-factor test was used to analyze the significance of the effect of each process parameter on the tobacco packet rewetting of moisture content, and then the Plackett-Burman test was used to screen out the parameters that had a significant effect on the moisture content. Finally, the regression response surface model of water content and each process parameter was established by the steepest climb test and BBD (box-behnken design) test. The results show that it is feasible to use the model to study the effect of each process parameter on the rewetting effect of tobacco packet. The gas-phase temperature, the gas-phase velocity, and rewetting time significantly influence the test results. When the gas-phase relative humidity is 90%, the gas-phase temperature is 61.71 ℃, the gas-phase velocity is 1.91 m/s, and the rewetting time is 378 s, the simulation results satisfy the response index. The research results can provide theoretical reference and data support for optimizing the tobacco packet rewetting process, reducing energy consumption and saving production costs.