The effects of climate change, such as increasing temperatures, altered precipitation patterns and intensities, and increased atmospheric CO2 concentrations, have a direct influence on plant development. These effects also have an impact on transpiration rates, yield, and productivity of plants. Abiotic and biotic stressors in crops are the most common repercussions of these climate change-related circumstances. Numerous studies are being conducted to find ways to mitigate the climate change-related repercussions and adapt to its negative effects on agriculture. The development of heat- and drought-tolerant crops, adjusting or modifying agricultural growth schedules, prudent resource management techniques, etc. are the primary foci of these research programs. Nonetheless, agronomic management and crop improvement through breeding programs can somewhat lessen the effects of climate change. According to a number of recent research, beneficial microbes can help agricultural plants become more resilient through plant–microbial interaction and may be a more effective way to mitigate biotic and abiotic stresses. Through a variety of processes, these bacteria can colonise the rhizosphere and/or endorhizosphere of crop plants, hence promoting the growth of these plants. In order to cope up the detrimental effects of stresses brought on by climate change and to develop response mechanisms for climate resilient agriculture, this book chapter will discuss the significance of these microorganisms and their potential to reduce stresses in crop plants.