In recent years, various agricultural research institutions in China have begun to increase the investment in informatization construction, so informatization brings great convenience to scientific research and management, but corresponding cybersecurity issues have become more and more important. Relying on the cybersecurity classified protection work, in-depth analysis of each weak link in the cyber system construction of agricultural scientific research institutions, to improve the information system security and avoid information security incidents has been placed in the prominent position of agricultural research institutions.[Method/Process] This article discusses the content of strengthening the cybersecurity management of agricultural scientific research institutions based on National Cybersecurity Classified Protection 2.0. First of all, this article introduces the importance of cybersecurity classified protection. Secondly, the difference between National Cybersecurity Classified Protection 2.0 standard and National Cybersecurity Classified Protection 1.0 standard is analyzed. Thirdly, the system of cybersecurity management and the content of cybersecurity management technology of Chinese Academy of Agricultural Sciences were analyzed in detail. Finally, it discusses and summarizes the effective strategies to strengthen the information security construction of agricultural research institutions. [Results/Conclusions] Taking the Chinese Academy of Agricultural Sciences as an example, this paper discusses its related practices in detail, hope to provide reference for agricultural research institutions to carry out cybersecurity level protection and security construction.