Nanofillers are increasingly being used in environmental industries to improve the performance of purification/separation materials. For example, nanofillers can be used to improve the strength and durability of products such as membranes and coatings, which can help treat/separate the waste produced. Nanofillers play a significant role in environmental remediation by blending them with conventional materials and implementing multifunctional properties. Strategic engineering of nanofiller-blends with respect to amount, synthesis strategy and impact assessment could favorably regulate the physicochemical properties of materials for better water and air purification and other environmental applications. Here, in this chapter, we wish to address advanced nanofiller types and their selection criteria, effective strategies to regulate the composition of nanofillers, and study their impact on property attunement for superior performance in the environmental field. This chapter shall serve as a reference for a comprehensive assimilation of recent advances in various types of nanofillers, their blending strategies, and selection criteria to favorably modulate material properties for effective performance in the environmental industry.