Nanotechnology is the molecular and atomic-level manipulation of matter. It has the potential to alter medicine and dentistry. Many researchers and dental practitioners have noticed the promising effects of nanotechnology on the prevention, diagnosis, and treatment of oral diseases. When nanotechnology is incorporated into dentistry, a new branch of practice known as nanodentistry emerges. By utilizing nanotechnology, dental materials can gain better characteristics and be enhanced. Nanodentistry creates any product from the base up using atomic components. There are many options, including nano-impressions, nanoceramics, and nanocomposites. Grains, fibers, crystals, nanoholes, films, and atoms are all forms of nanomaterials. Fillers that are nanoparticles in size and have low agglomeration and high dispersion can boost mechanical and antimicrobial capabilities. Nanofillers offer superior flow, hydrophilic characteristics, and reduced spacing at dental margins than traditional fillers. Nanofillers are now used to create more precise dental and gum impressions. By using nanofillers, a new class of dental restorative materials may be made with the ability to inhibit the production of cariogenic biofilm. This chapter aims to overview nanotechnology and its application in dentistry. In the following, we will mention the types of nanoparticle forms used in dentistry, focusing on nanofillers and their application. Ultimately, we will discuss the future use of nanotechnology and nanofillers in dentistry.