With the advancement of technology, especially in the applications based on artificial intelligence, many new avenues opened to the persons with disabilities (PwD) in improving their quality of life. This population faces different challenges across various domains. This chapter tries to explore the possibilities of multi-modal generative artificial intelligence (GenAI) on refining the lives of PwD. It also discusses various challenges of these persons in the areas of communication, mobility, education, and emotional well-being. The potential of multi-modal GenAI can address these major issues through augmentative and alternative communication (AAC), visual assistance, mobility assistance, personalised accessibility solutions, communication, intervention, education and employment, independent living, mental well-being, and emotional support. This chapter also discusses the recent trends and challenges in the implementation of multi-modal GenAI applications. Data privacy, bias, and technological barriers are indeed major concerns to be addressed in this regard. Finally, the paper highlights the future scope of multi-modal GenAI in progressing accessibility, inclusion, and empowerment for PwD, underscoring the potential for further innovation and collaboration in this crucial field of research and development.