To intercept high-speed, highly maneuverable targets at mid-to-high altitudes, this paper explores disturbance-rejection guidance laws for missiles with canard/tail rudder control. By integrating the canard/tail rudder composite control method with disturbance-rejection guidance laws, we significantly enhance the maneuverability, manipulation ability, and guidance precision of missiles. The optimal control algorithm refines the canard/tail rudder distribution strategy, while real-time disturbance-rejection compensates for unknown disturbances. Simulations show that this approach improves target interception performance and hit probability.