Aiming at the problem of high-precision attitude tracking of spacecraft clusters under the influence of dynamic change of communication topology and multiple disturbances. In this paper, a composite anti-disturbances strategy based on radial basis function (RBF) disturbance observer and distributed observer feedforward compensation plus feedback suppression is proposed. The RBF disturbance observer is used to estimate flywheel vibration disturbance, mass or inertial uncertainties caused by spacecraft fuel consumption, and space environment disturbance. The distributed observer estimates the leader attitude using local time-varying neighbor spacecraft attitudes. And the controller ensures that the spacecraft cluster attitude is coordinated. The stability of the designed control method is analyzed theoretically. Numerical simulation results verify the effectiveness of the proposed scheme.