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A 65-year-old lady presented with symptomatic anaemia (fatigue, dizziness) for several months, blood investigations revealing haemoglobin of 6.5 g/dL. Bidirectional endoscopy was normal, but CT abdomen and pelvis revealed a jejunal mass (Fig. 1). A small bowel resection confirmed gastrointestinal stromal tumour of spindle cell morphology, 6 cm with 6 mitoses per 5 mm2, margins clear, no rupture. Sequencing studies confirmed KIT mutation (exon 11 deletion). The patient received adjuvant Imatinib 400 mg once daily for 3 years. Two years after Imatinib discontinuation, she relapsed with peritoneal disease, for which Imatinib was reinitiated, achieving partial response.

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Gastrointestinal Stromal Tumours (GIST)

  • 章节

  • 发表日期：

    2025年

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  • Vincent Ern Yao Chan,
  • Joseph K. T. Lee,
  • James Thomas Patrick Decourcy Hallinan,
  • Timothy Kwang Yong Tay,
  • Mohamad Farid,
  • Jolene Si Min Wong,
  • Claramae Shulyn Chia,
  • Bok Ai Choo

摘要

A 65-year-old lady presented with symptomatic anaemia (fatigue, dizziness) for several months, blood investigations revealing haemoglobin of 6.5 g/dL. Bidirectional endoscopy was normal, but CT abdomen and pelvis revealed a jejunal mass (Fig. 1). A small bowel resection confirmed gastrointestinal stromal tumour of spindle cell morphology, 6 cm with 6 mitoses per 5 mm2, margins clear, no rupture. Sequencing studies confirmed KIT mutation (exon 11 deletion). The patient received adjuvant Imatinib 400 mg once daily for 3 years. Two years after Imatinib discontinuation, she relapsed with peritoneal disease, for which Imatinib was reinitiated, achieving partial response.