In Chiang Rai province, the intensity of heavy rain causes flash floods to increase, and children are particularly vulnerable to natural disasters. Because school is one of the locations where children spend substantial time during their formative years, school safety in disaster and emergency preparedness should be prioritized and managed effectively. This study examines the Comprehensive School Safety (CSS) Framework in Thailand with a case study from schools in Chiang Rai, with three pillars, (1) Safe Learning Facilities, (2) School Disaster Management, and (3) Risk Reduction and Resilience Education. By applying the qualitative method, this study reviews the literature from peer-reviewed journal articles on Disaster Risk Reduction (DRR) and School Safety in Thailand for two decades (2000–2020) to identify good practices and challenges in DRR and School Safety fields. The study applies in-depth interviews and develops survey questionnaires to the respondents’ administrators and teachers in one primary school in Chiang Rai regarding its CSS framework implementation. Results show that the school has created and implemented a student curriculum on DRR as endorsed in the CSS Framework. The basic core curriculum of DRR learning in Thailand starts from pre-school grade 6 to grade 12. However, there is still a lack of teacher training programs and school children's participation in drills and training. Several challenges include financial and human resources limits. Moreover, with the increasing frequency and intensity of disasters in Thailand, the DRR in education should cover multi-hazards preparedness to help school children gain preparedness knowledge and readiness attitude and mitigate emergencies effectively.