Earthquakes are considered natural disaster, and it causes widespread destruction, loss of life, and significant impact on buildings. Ground motion due to seismic wave during an earthquake exerts lateral forces on structures and lose its strength and leading to a phenomenon known as soil liquefaction. It leads to devastating the buildings, making them more vulnerable to damage or collapse. Buildings should withstand the impacts of earthquakes, for ensuring the safety of occupants and reducing the structural damages. Embedment of seismic isolation materials in soil is an effective method employed to enhance the building’s seismic resilience. By incorporating the isolation materials in soil, buildings will experience reduced accelerations and displacements during seismic events and correspondingly leading to less structural damage. Seismic isolation materials have the damping property, therefore it absorbs the seismic wave energy and thus preventing excessive forces acting on the structure. This study investigated the efficiency of coir polyester, polyurethane (PU) foam, and geomembrane as isolation materials. In order to study the effectiveness of these isolation materials, seismic responses such as roof acceleration, displacement, and storey drift of G + 4 building was analysed using ANSYS software. This work focused to propose the effective depth and thickness of the most effective isolation material that reduces the seismic energy transferred. On other hand this work proposes a cost-effective method for mitigating the impact of earthquakes on buildings.