This study aims to assess the effect of near-field earthquakes on base-isolated (BI) building frames considering soil-structure interaction (SSI). For this purpose, a five-story base-isolated building frame equipped with lead core rubber bearing (LCRB) isolator was considered. Nine near-field earthquakes, categorized into low, intermediate, and high based on their ranges of peak ground acceleration to peak ground velocity (PGA/PGV) ratio, were selected for analysis. Further, four different combinations of bases are considered to investigate the effect of SSI, and the seismic responses of the building with these combinations are compared. The study focuses on isolator displacement, peak base shear, and peak roof acceleration as the key response parameters. The analysis results are indicative of the influence of frequency contents in near-field earthquakes by obtained by varying (PGA/PGV) ratio in spite of the fact there are other characteristics such as amplitude and duration which may affect the responses. The findings indicate that isolator displacement and base shear demands of BI frames reach their maximum levels under near-field earthquakes having low PGA/PGV ratio or ground motion frequency content. However, maximum top-floor acceleration was observed under the ground motions having an intermediate PGA/PGV ratio. These trends persist consistently across both scenarios, where soil-structure interaction effects are incorporated and when they are neglected in the analysis. The results also show that the structural response control performance of LCRB is compromised due to the consideration of SSI effects.