Road safety has become an utmost concern in the Indian context, prompting a comprehensive investigation into the matter within the populous urban center of Nagpur. In the year 2022, Nagpur encountered an alarming tally of 3268 road accidents, tragically resulting in an excess of 1000 fatalities and over 2000 injuries. Of particular note, a significant portion of these incidents involved two-wheelers, accentuating the critical need for targeted interventions addressing this distinct class of road users. This research endeavors to meticulously analyze the multifaceted determinants underpinning road accidents and data analysis. To realize this objective, an intricate methodology was deployed, centered around geospatial analysis and the discerning technique of kernel density estimation for calculation of Road Safety Risk Index. By adopting this approach, the identification and cartographic delineation of precarious zones within the urban road network were facilitated, thereby illuminating the spatial dispersion of accidents. The strategic utilization of geo-mapping and spatial analytical methodologies culminated in a holistic comprehension of the unsafe road matrix, thereby affording pivotal insights into the epicenters where accidents were markedly concentrated. Moreover, the research ingeniously established a Road Safety Risk Index encompassing all links, achieved through a weighted severity analysis (crash rate, exposure, probability, and consequences of accidents). The ramifications of this research conspicuously underscore the relevance of spatial analysis in comprehending the intricate dynamics of road safety, particularly concerning two-wheeler accidents. In summation, this research substantially contributes to the discourse surrounding road safety in India, with a specific emphasis on the exigent challenge of two-wheeler accidents in Nagpur.