China's economic model is undergoing a transition from extensive growth to high-quality development, a transformation that has been significantly reinforced within the context of regional integration strategies. Logistics enterprises play a pivotal role in driving high-quality economic development, particularly in the Yangtze River Delta region. This research, framed within the context of the Yangtze River Delta regional integration strategy, analyzes the dynamic changes in the spatial layout, organizational networks, and driving mechanisms of logistics enterprises. The findings aim to assist national and local governments in formulating development plans for logistics enterprises that align with the requirements of regional integration, thereby achieving healthy, sustainable regional logistics development and contributing to overall economic growth.