The unavoidable prerequisites for the superior development of China’s economy are the promotion of digital industrialization and digitization as well as the deep integration of digital technology and the actual economy. The coupling coordination degree model is used in this paper to analyze the coupling coordination between the advanced manufacturing sector in Dongguan and the digital economy. The results show that, from 2011 to 2020, the composite index of the advanced manufacturing sector and digital economy in Dongguan shows a gradual upward trend, with both sectors’ coupling coordination degrees moving from mild dysfunctions to high-quality coordination. According to the comprehensive index, Dongguan’s advanced manufacturing sector should be centered on the advancement of greening, enhance profitability and innovation capacity, and create a better environment for the real-world implementation of the digital economy. Dongguan’s digital economy also has room for improvement in the communication infrastructure, in addition to maintaining its advantages in the field of information technology.