The operation plan of high-speed rail directly affects the competitiveness of passenger transport products, necessitating a sound evaluation scheme for timely adjustments. The evaluation of the existing operation plan mainly focuses on a single train, which cannot reflect the impact of high-speed rail network operation. From the perspective of complex network, a new concept of route matching is proposed. Taking a single train as the object, indexes are selected from three aspects: path matching, economic benefit, and transportation efficiency, and an evaluation index system for the benefit efficiency of the high-speed railway operation plan oriented to the road network is constructed. An evaluation model based on improved TOPSIS-factor analysis is proposed. Taking the high-speed rail network with the Beijing-Shanghai high-speed railway as the backbone for example, this paper optimizes the operation plan from the perspective of adjusting the train running path and provides some reference for the operation department.