Groundwater is an important source of drinking water for the majority of people on the earth. As a result of increasing urbanization and industry, both the quantity and quality of groundwater are under significant stress. Anthropogenic activity is one of the most important environmental elements that, in some areas, contribute to groundwater contamination. A study was undertaken in the Srivaikundam area of the Thoothukudi district of Tamil Nadu, India, in order to construct a dramatic vulnerability index in a GIS environment due to groundwater pollution induced by a rise in commercial, industrial, and agricultural activity. The analytical hierarchy technique employed in this work incorporates both remote sensing and geographic information systems. The layers and their attributes were allocated to Saaty’s scale, which was properly weighted to take into consideration their importance for groundwater occurrence. Seven different hydrogeological parameters were layered using the data that was available to create a map of groundwater vulnerability (depth to the water table, net recharge, aquifer media, soil media, topography, vadose zone, and hydraulic conductivity). Arc GIS software was used to find groundwater-vulnerable zones in the research area. This GIS technique has enhanced groundwater pollution vulnerability analyses. The final severe index map was separated into five groups based on the percentage regions of 0.21, 28.32, 52.54, 11.64, and 7.30%. Susceptibility levels include extremely low, low, medium, moderate, and very high.