Current transformations highlight the role of innovationInnovation in the performancePerformance of organizations and in the future of work. This demonstrates the importance of companies making innovationInnovation compatible with better environmental, social, and governanceEnvironmental, social and governance practices, known as ESG, since this relationship influences stakeholdersStakeholders and the territory. This chapter seeks to present the regional factors of innovationInnovation and some perspectives on the future of work, emphasizing the importance of ESG dimensions for understanding the role that organizations can play in socialSocial developmentDevelopment and the territories in which they operate. Using case studiesCase studies with ESG experiences, reflections, and cases to be solved, the aim is to demonstrate that the efficient managementManagement of resources, innovationInnovation and investmentInvestment in human capital are key to boosting the competitivenessCompetitiveness and success of organizations.