Gut hormones are known to play a critical role in the regulation of appetite and energy expenditure. Some of the important hormones that have been explored in the management of obesity includes ghrelin, glucagon-like peptide 1 (GLP-1), peptide tyrosine-tyrosine, oxyntomodulin, glicentin, pancreatic polypeptide, amylin, and cholecystokinin. Imbalance in the level of these hormones likely contributes to the development of obesity. The role of these gut hormones has received a lot of attention in the last few years as important therapeutic targets in the management of obesity.