Cellular structures are porous materials that exhibit unique physical and mechanical properties primarily determined by their topology and fraction volume rather than their characteristics and properties related to the structures and the chemical compositions. In this study, cellular structures were derived from the owl bird’s feathers, mimicking the structural design of the owl’s feather; using Solidworks, a CAD model was prepared, and further fused filament fabricated (FFF) 3D printing technique was used to create the structures. All the structures are printed with Polylactic Acid (PLA) material. Experimental analysis of these structures under uniaxial compressive tests was carried out. The literature shows that the compressive strength and energy absorption of bio-inspired structures are good as compared to the other cellular structures. We further studied how the change in shape of the strut, which varied between square, hexagonal, and circular, along with variation in loading direction, changes the load bearing capacity and energy absorption capacity under compressive load. The direction of load was varied in three different directions, i.e. along the rachis, perpendicular to the rachis, and perpendicular to the barbs plane. Overall, it was observed that the bio-inspired structure showed significant variation as the load direction changed; the effect of the shape of the strut also showed conclusive results of the hexagon-shaped strut structure being able to absorb maximum energy. These bio-inspired designs have the promise for 3D-printed structure application in various fields with superior mechanical properties without compromising the structural strength.