Additive manufacturing can fabricate lattice structures with complex geometries as well as unique properties. The lattice structure is composed of a unit cell which is filled in a space along the three axes with no gaps. In these structures, the unit cell orientation considered either periodic known as strut-based structures or random known as Voronoi structures. A comparison of mechanical behavior and energy absorption capability was carried out between strut-based structures and Voronoi structures. The strut-based structures considered here are Octet Truss (OT), rhombic dodecahedron (RDDH), and Diamond (DM). The Voronoi structures can be characterized as stochastic and non-stochastic. These structures were designed and printed with the same relative density as strut-based structures, on fused deposition modeling (FDM) technology. Acrylonitrile butadiene styrene (ABS) and poly lactic acid (PLA) are the materials used to print the structures. The printed lattice structures were quasi-statically tested in compression. The experimental results showed that mechanical properties and deformation mechanisms depend on the number of unit cells, unit cell type, cell orientation, bulk material properties, and printing direction. The fracture behavior was noted as elastic buckling, strut collapse, and de-bonding of weak layers. The lattice structures are categorized as bending-dominated and stretching-dominated structures. The material reactions to the mechanical properties of the Voronoi structures were studied. By considering all the results, the best lattice structure with high elastic energy absorption capability was used to design the WristSplint for real-time applications.