The Philippines faces regular natural disasters, including tropical typhoons. These strong winds, particularly from typhoons, can damage structures, especially non-engineered residential buildings. Despite limited solutions for mitigating natural disaster impact, biomimicry offers a potential approach. Biomimicry imitates Nature’s principles to create sustainable solutions with minimal energy use. By applying this concept, the study aims to analyze and apply biomimetic design to enhance the wind resistance of residential structures in the Philippines. This research paper focuses on assessing the impact of wind forces on typical residential houses versus houses with biomimetic design, utilizing Autodesk Simulation CFD for aerodynamic simulations. Wind speeds ranging from 60 to 290 kph represent tropical depressions to super typhoons. The study employs structured observation techniques to compare wind pressure and lateral resisting force between the house types. The simulated Biomimetic house underwent wind speeds of 60 kph, 88 kph, 117 kph, 220 kph, and 290 kph. The front and side of the house showed a mean pressure of 0.81208754 kPa and 0.62699424 kPA, respectively, meeting NSCP standards for Open, Hip, Dutch-type, and Jerkinhead houses. Using statistical tools for determining the significant difference between the biomimetic house data and NSCP provisions for various types of houses, the study’s findings affirm the reliability and safety of the simulated Biomimetic house, which can endure wind pressures compared to those experienced by different house types. These insights are valuable for architecture, engineering, and construction professionals seeking to design and construct houses resilient to extreme weather conditions, including strong winds.