Investigating the site-specific mechanical behavior of sand under cyclic loading holds crucial importance in geotechnical and many other engineering applications. The Sutlej River sand has been used in the present study because of its high liquefaction susceptibility, as the Sutlej River lies in the high-risk seismic zone in the northeastern part of the Punjab state. The comparative study between the in situ Sutlej River procured sand and Natural rubber latex (NRL) treated Sutlej sand has been done by employing stress-controlled cyclic triaxial tests under varying experimental conditions. The testing has been performed over different confining pressures under varying material circumstances, i.e., different concentrations of permeated NRL solution and relative densities. The number of cycles required for onset of liquefaction has been investigated using the cyclic triaxial test. It has been shown by testing that the number of cycles necessary for the onset of liquefaction increased with an escalation in the relative density and NRL concentration. The present study reveals that introducing NRL into the sand is an efficient technique for improving the mechanical behavior of sand under cyclic loading. Therefore, the NRL permeation technique can be used as an effective liquefaction mitigation measure for the locally available sands.