One of the most inconvenient problems in membrane technology is accumulation of particles on the surface of the membranes which paves the way to membrane fouling. That eventually leads to decline in membrane performance like productivity and selectivity, which enhances the membrane treatment costs. Improving the hydrophilicity of the membranes is alternate way to decline the membrane fouling. Therefore, the use of different additives or fillers has been suggested for enhanced membrane performance in terms of permeability, fouling resistance, and separation qualities. However ceramic particles show tremendous impact on this concept. Thus, this chapter presents a recent progress in polymeric mixed matrix membranes containing ceramic additives or fillers. Usually, the bonding in ceramic nanofillers are ionic, covalent, and sometimes Van-der-Waals interactions. The usage of ceramic fillers as nanoadditives in polymeric mixed matrix membranes for wastewater treatment is increasing rapidly due to their adaptable functions, size, composition, and morphology, which provide limitless possibilities for wastewater treatment. Several literatures are demonstrating the outstanding ability of ceramic fillers in mixed matrix membranes. The influence of ceramic fillers in different polymers such as polysulfone, PVDF, PES, and its role in antifouling property is highlighted in this chapter. Finally, critical challenges for future study on mixed matrix membranes modified with ceramic fillers are suggested.