Additive manufacturing has been one of the most tremendously growing technologies in the manufacturing paradigm. Its advantages have propelled this technology as the most sought-after in various fields of industries. This technology has also been utilized to fabricate oral tablets and they have shown personalized release behaviour that act as per the metabolic needs of patients. The aim of this research work was to analyse the degradation behaviour of 3D-printed tablets, loaded with drug, in body fluid conditions. Computer-aided designs of tablets having hybrid infill structures were created and loaded into COMSOL software for analysis. The degradation of the loaded models of tablets has been carried out using modelling governing equations of previous literatures. Then, the results obtained using the computational analysis were analysed with the experimental in-vitro studies conducted for the Fused Deposition Modelling (FDM) fabricated polyvinyl alcohol (PVA) tablets loaded with myo-inositol drug in the previous study of the authors. It was found that the results obtained from the computational analysis were in agreement with that of the experimental data. There were slight errors found between the two plots for all the tablet formulations. This can be attributed to the values of the diffusivity constants used during the simulation of differential equations in the software. The present work can be essential contribution towards the assessment of feasibility of additively manufactured tablets as a means of achieving the goal of personalized medication.