The effectiveness of bio-based foam sorbents in oil spill cleanups is determined by a complex interplay of factors that influence their absorption capacity, durability, and adaptability to diverse environmental conditions and oil types. This chapter delves into nine primary factors impacting the performance of these sorbents: material composition, physical properties, chemical properties, mechanical properties, thermal stability, environmental conditions, operational parameters, recyclability and reusability, and environmental impact. Each of these factors plays a significant role in enhancing the efficacy and sustainability of the sorbents under various conditions. We begin by examining the fundamental capabilities of the sorbents, focusing on how each property enhances its efficiency in different ecological settings and temperature conditions. This analysis leads to a discussion of operational parameters to shed light on the practical deployment and effectiveness of the sorbents in field conditions. The chapter then transitions to considerations of recyclability and reusability, emphasizing the sustainability of these materials in alignment with eco-friendly initiatives. Lastly, we assess the broader ecological implications of using bio-based foam sorbents in oil spill responses. By thoroughly understanding and optimizing these properties, bio-based foams can be tailored to effectively meet the challenges of real-world spill remediation, offering a sustainable alternative to synthetic options and addressing global environmental hazards.