This chapter explores the theme of sustainability through a re-evaluation of the Sustainable Development Goals, focusing on prosperity and its essential role in achieving true sustainability. It examines the sustainability of healthcare systems through the lens of prosperity, highlighting how current norms often undervalue prosperity and poverty. Generic universal norms tend to overlook specific viewpoints, such as those of large industrial players or Low-Resource Settings, leading to exclusion and reduced effectiveness, thereby hindering environmental sustainability. Recognizing this issue, both the World Health Organization (WHO) 2025–2028 agenda and the International Federation of Medical and Biological Engineering (IFMBE) strategic plan are now addressing the need for ecological sustainability in healthcare. This essay aims to shed light on an interdisciplinary framework that integrates environmental, health, business, regulatory, and ethical dimensions, emphasising that progress in sustainability requires maintaining this multifaceted perspective.