This chapter provides a comprehensive analysis of Climate-Smart Agriculture (CSA) practices in Odisha, highlighting their impact on agricultural productivity, resilience, and sustainability. The chapter begins by discussing the significance of CSA in addressing the intertwined challenges of food security and climate change, particularly in an agrarian state like Odisha. Various CSA practices such as stress-tolerant rice varieties, non-puddled transplanting, direct seeded rice, and integrated nutrient management are explored in detail. Each practice is analyzed based on key metrics including machinery usage, diesel consumption, labor requirements, costs, energy inputs, and savings. The findings indicate substantial benefits from adopting CSA practices, including enhanced crop yields, reduced resource usage, and improved economic returns for farmers. Additionally, the chapter delves into the socio-economic context of Odisha, emphasizing the vulnerabilities of smallholder farmers to climate change. The importance of capacity building, participatory approaches, and supportive policy frameworks is underscored to ensure the successful implementation and scaling of CSA practices. The chapter concludes with recommendations for future directions and policy enhancements to sustain and expand the benefits of CSA in Odisha, ultimately aiming to improve food security and farmer livelihoods while mitigating environmental impacts.