The seismic response of pile foundations is generally studied considering a single earthquake motion. The effect of repeated shaking on the response of foundations is generally neglected. However, the aftershocks can be as strong as the main earthquake. The present study focuses on understanding the response of vertical pile foundations under multiple earthquake scenarios. A 2 × 1 vertical pile group embedded in a homogeneous layer of sandy soil is considered for the study. The modeling and analysis are carried out using the finite element software package OpenSees. Time history analyses are performed to study the effects of the following (a) characteristics of the main shocks and aftershocks; (b) time gap between the shocks; and (c) relative density of the soil. The results indicate that both magnitude and PGA of mainshock and aftershock influence the induced bending moment in piles. Also, considering a single earthquake time history in predicting the performance of a foundation can considerably underestimate the settlement of the foundation system.