This chapter aims to address key issues at the intersection of suicidality and posttraumatic growth (PTG) and provides guidance for considering PTG-based theory in suicide prevention and intervention research and practice. We present a generative research and intervention framework that includes (a) an examination of how theoretical models of suicide and PTG overlap, (b) presentation of a theoretical posttraumatic growth-based suicide prevention and intervention model, termed “Connection-Regulation-Hope” (CRH), (c) a clinical framework aimed at increasing the clinician’s ability to prevent and intervene in suicide, and (d) a roadmap for PTG-based suicidality research aimed at discovering more about how and why experiences of PTG offset risk for suicide. Our PTG-based model of suicide intervention integrates elements of cognitive–behavioral, narrative, interpersonal, and existential therapies while emphasizing the importance of the therapy relationship using the “expert companionship” approach.