In this work, a LLCC resonant driving scheme for high-power piezoelectric transducers considering optimal driving frequency was proposed, at which working frequency the power dissipation of the transducer arrived at its minimum level. Based on the mechanical quality factor theory, the optimal working frequency from the loss reduction viewpoint was initially derived by electromechanical equivalent circuit of the piezoelectric transducer. Secondly, a LLCC resonant network was proposed to matching to the transducer at the optimal driving frequency, and the load characteristics can be changed from inductive to approximately resistive. Based on the switching circuit with push-pull topology, the proposed LLCC-resonant driving scheme at the optimal working frequency was validated by simulation and experiment, which possesses excellent performances of low power dissipation and invariant output characteristics under different operating conditions.