To improve the reliability and anti-interference capability of the actuator drive system onboard aircraft, this paper proposes a novel open, full-digital, high-integrity drive system design method based on permanent magnet brushless motors. The drive system is equipped with multiple protection circuits at the power input stage to deal with and suppress various non-normal power inputs such as overvoltage, under-voltage, overcurrent, and lightning strikes. At the bus input stage, an improved protocol-based, question-and-answer open communication CAN bus is adopted to improve the stability of external communication. In the digital control stage, a dual-channel, full-digital, dual closed-loop control method is adopted to achieve high integrity of the drive system. In the execution stage, a permanent magnet brushless motor is used as the load movement actuator. Finally, a hardware prototype was built for experimental analysis, and the power input protection function, waveform of the motor control link, and control accuracy of the drive system over the full range of the actuator were recorded and calculated. The experimental results show that the drive system has excellent performance, high control precision, and can be used as a reference for the design of actuator drive systems onboard aircraft.