With the access of distributed power and energy storage devices, the distribution network becomes more and more complex, and how to find the vulnerable nodes in the distribution network has attracted much attention. In this paper, a comprehensive vulnerability assessment method of distribution network is proposed from two aspects: structural vulnerability and state vulnerability. Structural vulnerability includes three evaluation indexes: improved node degree, improved node intermediate number and percentage of load loss. State vulnerability includes node voltage overlimit and line overload indicators. Through the improved IEEE33-node distribution network, the proposed vulnerability index is verified and analyzed, and the results show that the evaluation index proposed in this paper is consistent with the actual situation, which fully proves its rationality and effectiveness.