Earthquakes are natural occurrences responsible for significant damage to foundation soils globally. The extent of soil and structural damage during earthquakes is contingent upon the dynamic properties of the soil profile and its response to varying levels of acceleration. The underlying ground layers and their seismic wave propagation velocities influence severe ground motion destruction. Ground Response Analysis (GRA) aims to forecast soil behaviour at different depths in a region under seismic loading, ensuring the structural integrity to withstand such forces. This study focuses on the 1D ground response of soil deposits in the Kunnamangalam Area of Calicut, Kerala, India. Field investigation data was utilized with multichannel analysis of surface waves, generating soil profiles from 48 sites for the GRA. The seismic input motion from the Jorhat earthquake (Mw-5.8) in the Phek-Nagaland area, with a Peak Ground Acceleration (PGA) of 0.031g, was applied to these profiles for 1D ground response analysis. ProSHAKE software was used to conduct the ground response analysis, resulting in surface PGA values ranging from 0.033 to 0.062 g. The ratio of response spectra between the soil surface and outcropping base rock, known as the amplification factor for the study area, was found to be in the range of 1.06 to 2.13, despite the region being categorized as zone III according to the Seismic code of India (IS: 1893–2016). Therefore, it is crucial to assess potential soil amplification by earthquakes when planning construction in this region, especially when building earthquake-resistant structures.