Vellore is one of the important cities of Tamil Nadu state and is situated in a region classified as seismic zone III (IS 1893 (Part 1), 2016) which has many densely populated buildings, and hospitals. A comprehensive probabilistic seismic hazard analysis (PSHA) was conducted in the study area using the Cornell approach. A circular source region encompassing all faults and lineaments within a 500 km radius was considered for seismic assessment. A comprehensive earthquake catalogue was assembled from diverse literature and organizations, with various magnitude scales harmonized into a consistent moment magnitude scale (Mw). Due to the repetition of events, the foreshocks and the aftershocks have been removed from the main events with a declustering method. The ground motion prediction equation (GMPE) has been used to calculate the ground motion parameters. The peak ground acceleration (PGA) has been evaluated using the Cornell approach for a 10% exceedance probability with respect to a 475-year return period for the bedrock condition. The uniform hazard response spectra (UHRS) for the study area has been compared with (IS 1893 (Part 1), 2016). A predominant magnitude and distance pair have been calculated from the de-aggregation analysis which was responsible for the major contribution of the hazard.