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The tumor-immune microenvironment (TME) is a dynamic and complex ecosystem where metabolic communication between tumor cells and immune cells plays a crucial role in shaping tumor progression and therapeutic responses. In the middle of tumor invasion mechanisms and immune defense interactions, metabolites play a mediator role in the fate of TME stability. This chapter provides a comprehensive analysis of the metabolic interactions within the TME, focusing on how tumor cells alter the metabolic landscape to influence immune cell function and vice versa. We will discuss the key metabolic pathways involved, the effects of metabolic changes on immune cell activity, and the implications for developing novel therapeutic strategies.

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The Mechanisms and Therapeutic Implications of Metabolic Communication in the Tumor-Immune Microenvironment

  • 章节

  • 发表日期：

    2025年

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  • Mahmoud Singer,
  • Rania Hamdy,
  • Tasneem M. Elsayed,
  • Mohamed I. Husseiny

摘要

The tumor-immune microenvironment (TME) is a dynamic and complex ecosystem where metabolic communication between tumor cells and immune cells plays a crucial role in shaping tumor progression and therapeutic responses. In the middle of tumor invasion mechanisms and immune defense interactions, metabolites play a mediator role in the fate of TME stability. This chapter provides a comprehensive analysis of the metabolic interactions within the TME, focusing on how tumor cells alter the metabolic landscape to influence immune cell function and vice versa. We will discuss the key metabolic pathways involved, the effects of metabolic changes on immune cell activity, and the implications for developing novel therapeutic strategies.