Vascular access in pediatric patients is a fundamental aspect of clinical care, enabling the administration of fluids, medications, blood products, and nutritional support. Due to anatomical and physiological differences, obtaining and maintaining vascular access in children presents unique challenges compared to adults. Securing vascular access in pediatric patients can be a complex task, especially in scenarios such as complex surgical procedures, resuscitation, invasive monitoring in intensive care unit (ICU)s, frequent hospitalizations, chemotherapy, extracorporeal membrane oxygenation, or long-term parenteral nutrition support. Health care providers working in pediatric clinical settings must be proficient in various vascular access techniques, maintenance protocols, and the management of associated complications. Advancements in image-guided vascular access have significantly improved success rates and reduced complications.