The business world is rarely clear-cut. Everyday challenges involve shades of gray, incomplete information, and varying levels of truth. Traditional decision-making tools often struggle with this inherent ambiguity. However, a new approach is emerging: human-centric computing that embraces uncertainty. This chapter explores the application of human-centric computing in tackling real-world business problems. It introduces core concepts like flexible reasoning and probabilistic analysis, showcasing their effectiveness in areas like risk management, resource allocation, and marketing campaigns. Through a chosen case study, the chapter demonstrates how human-centric computing empowers businesses to make informed decisions even in the face of uncertainty. The chapter concludes by highlighting the potential of this approach to revolutionize business decision-making in the age of information overload.