This chapter investigates constraints faced by organisations in promoting technological innovations for sustainable development in South Asia. The study, conducted using a systematic literature review with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Population, Interest, Context, Outcomes (PICO) approaches, focuses on various obstacles detrimental to organisational initiatives in sustainability using 35 sample studies. The findings show that regulations, funding, technology, and culture impact innovation as it is implemented in South Asia's energy, agriculture, and manufacturing sectors. The research acknowledges the areas of improvement, especially highlighting the need for improving government and private partnerships, favourable legal conditions, and improvement of institutional capacity. Against this background, organisations have to undertake collaborative strategies consistent with the international sustainable development framework to address the challenges faced and encourage the promotion of newer technologies. Alleviating such constraints would indeed enhance the status and further the missions of key organisations in a far-reaching manner in South Asia and the larger region for a more sustainable course and future.