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Tumor cells located distal to the functional blood vessels often experience hypoxic stress during tumor progression. Intratumoral hypoxia is known to promote angiogenesis, tumor metastasis, and the development of chemoresistance and radioresistance. The hypoxia-inducible factor 1 (HIF-1) and HIF-2 signaling pathways are two of the most studied pathways known for their roles in regulating the survival of cells, including tumor cells, under hypoxic conditions. This chapter discusses the regulation and effects of the HIF-1/HIF-2 signaling pathway in cells under normoxic and hypoxic conditions. The potential of re-oxygenation and targeting the HIF-1/HIF-2 signaling pathway as anticancer therapies will also be discussed in detail.

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Hypoxia-Inducible Factors: Regulation and Therapeutic Potential

  • 章节

  • 发表日期：

    2025年

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  • I-Li Lin,
  • Kwang-Yu Chang,
  • Fong-Yu Cheng,
  • Rupinder Kaur Kanwar,
  • Pramedha Kamplikar,
  • Jagat Rakesh Kanwar,
  • Chun Hei Antonio Cheung

摘要

Tumor cells located distal to the functional blood vessels often experience hypoxic stress during tumor progression. Intratumoral hypoxia is known to promote angiogenesis, tumor metastasis, and the development of chemoresistance and radioresistance. The hypoxia-inducible factor 1 (HIF-1) and HIF-2 signaling pathways are two of the most studied pathways known for their roles in regulating the survival of cells, including tumor cells, under hypoxic conditions. This chapter discusses the regulation and effects of the HIF-1/HIF-2 signaling pathway in cells under normoxic and hypoxic conditions. The potential of re-oxygenation and targeting the HIF-1/HIF-2 signaling pathway as anticancer therapies will also be discussed in detail.