Battery thermal management system (BTMS) which is cooled by liquid coolant is an efficacious and productive thermal management solution to dissipate the heat that is released during charging and discharging of battery pack because traditional cooling methods are not able to maintain the temperature of the battery pack in desired temperature range. Various cooling methods to achieve zero or negligible nonuniform temperature distribution of lithium-ion battery packs are recommended, and numerical simulations are used to evaluate their effectiveness. For demonstrating suggested strategies, a serpentine channel is being used, and coolant is flowing through it to cool lithium-ion battery cells. In this work, an optimized design of serpentine cooling tubes is suggested to lower the thermal nonuniformity of LIBs with favorable pressure drop. A lithium-ion battery pack having 36 18650-type battery cells is subjected to a thermal model that has undergone extensive testing. On the other hand, to enhance thermal nonuniformity, two different strategies are being employed: (1) passing coolant through a cooling tube in a single flow and (2) using multiple mini-channels to pass coolant through the tube. The outcomes of the numerical simulation is that these two selective approaches are able to reduce the nonuniformity of temperature and maximum temperature of the LIBs of 5C discharge rate, up to 2.04 K and 308.75 K, respectively. As we increase the number of channels, maximum temperature of battery cells decreases. In this chapter, the functional viability, illustration, and performance of various methods are comprehensively discussed.