Isogeny-based cryptography is cryptographic schemes whose security is based on the hardness of a mathematical problem called the isogeny problem, and is attracting attention as one of the candidates for post-quantum cryptography. A representative isogeny-based cryptography is the signature scheme called SQIsign, which was submitted to the NIST PQC standardization competition. SQIsign has attracted much attention because of its very short signature and key size among the candidates for the NIST PQC standardization. Recently, a lot of new schemes have been proposed that use high-dimensional isogenies. Among them, the signature scheme called SQIsignHD has an even shorter signature size than SQIsign. However, it requires 4-dimensional isogeny computations for the signature verification. In this paper, we propose a new signature scheme, SQIsign2D-East, which requires only two-dimensional isogeny computations for verification, thus reducing the computational cost of verification though increasing the signing cost. First, we generalized an algorithm called RandIsogImg, which computes a random isogeny of non-smooth degree. Then, by using this generalized RandIsogImg, we construct a new signature scheme SQIsign2D-East.