This chapter provides a comprehensive exploration of primary healthcare systems across the Asia–Pacific region and beyond, comparing the diverse approaches adopted by key countries such as Australia, Japan, Singapore, Malaysia, Vietnam, Indonesia, the Philippines, and the United Kingdom. The analysis delves into healthcare policies, financing models, and access to services, highlighting challenges such as disparities in care, workforce shortages, and the need for sustainable financing. The chapter also examines innovative solutions, including telemedicine, digital health, and integrated care models. Comparative insights from other global regions, such as Europe, North America, and Africa, are discussed, alongside lessons that the Asia–Pacific can teach the global healthcare community. The chapter concludes with policy recommendations and strategic directions for strengthening primary healthcare systems globally, with a focus on building resilient and equitable healthcare systems for the future.